Meth Crossing the Blood-Brain Barrier

meth

Mind-altering chemicals, like drugs and alcohol, do just that, they change your state of mind. Naturally, each drug has its own unique effect and how a person responds depends on the substance in question. Any individual with a history of alcohol or substance use disorder has a first-hand understanding of what such experiences are like; however, few people with such pasts know what a particular chemical "actually" does in the brain, or to the most vital organ.

Those who’ve undergone treatment may have a cursory understanding of mechanisms like the blood-brain barrier (BBB). The term is defined as a filtering mechanism of the capillaries that carry blood to the brain and spinal cord tissue, blocking the passage of certain substances. When a person uses a mind-altering substance, the particular drug makes its way into the bloodstream and onto the brain. While not everything that enters the bloodstream can pass the barrier, the materials that lead to use disorders do; and, can cause damage in the process of crossing the threshold.

In a fundamental sense, the BBB lets healthy things into your brain cells and prevents anything harmful, like toxins from entering. Researchers at the Harvard’s Wyss Institute for Biologically Inspired Engineering say that when drugs like methamphetamine pass the barrier, the substance increases the permeability of the BBB, Motherboard reports. Meaning, other harmful toxins found in the blood may find their way across, too.

Artificial Brains On Meth

Advancements in technology allow researchers to create artificial human brains involving the integration of human cell cultures into microfluidic chip platforms, according to the article. This process may sound complicated, only understandable to scientists; however, it is possible for non-specialists to grasp the concept. The research team at Wyss are using microchips lined with living human cells which are then introduced to drugs like meth, to observe responses and stimuli. The research findings appear in Nature Biotechnology.

“Our primary reason for choosing this drug is that it is one of the most addictive drugs responsible for thousands of deaths,” writes co-lead researcher Ben Maoz. “Given this tragic statistic, it is surprising that much is still unknown. Therefore, we sought to use this novel system to unveil the metabolic effect of meth on the different parts of the [neurovascular unit].”

Please take a moment to watch a short video for a basic understanding of the process:


If you are having trouble watching, please click here.

“Just like in the brains of people who choose to smoke meth, the BBB chips started to leak,” Kit Parker, professor of Bioengineering and Applied Physics, told Digital Trends. “That’s exactly what happens when you smoke meth — and why you shouldn’t.”

Developing a more concise understanding of how narcotics interact with the human brain can have enormous implications. The research may lead to more effective methods of treating addiction, according to the article. What’s more, the findings could help scientists discover new processes of transporting beneficial pharmaceuticals to the appropriate brain targets. Lead researchers Ben Maoz, Anna Herland, and Edward Fitzgerald are developing new Organ Chip platforms applicable to neuropathology research on stroke, Alzheimer’s disease, and traumatic brain injury.

We took a game-changing advance in microengineering made in our academic lab, and in just a handful of years, turned it into a technology that is now poised to have a major impact on society,” said Donald E. Ingber, M.D., Ph.D., is the Founding Director of the Wyss Institute for Biologically Inspired Engineering at Harvard University, who was not involved in the study.

Biologically inspired engineering may have near-limitless potential when it comes to studying the impact of psychostimulants on the brain, in real time. It also means that drug research – one day – may no longer require soliciting addicts and alcoholics in the grip of use disorders to participate in studies that involve using addictive substances.

Substance Use Disorder Treatment

Please contact PACE if you or a male loved one is battling alcohol or substance use disorder. At our treatment center, we address all components of addiction and mental health. Please call to speak to an admissions counselor who can answer any questions you have about our gender-specific, extended care alcohol and drug rehab for men.

Sobriety: Making Positive Life Changes

sobriety

Aside from being a highly acclaimed novella by Franz Kafka, metamorphosis is also a word that holds particular significance for people transforming their lives via programs of addiction recovery. A definition of the noun states a change of the form or nature of a thing or person into an entirely different one, by natural or supernatural means. If that doesn’t nicely sum up sobriety, and the effect it can have on an individual’s life, then what does?

If you read the novel in school or for leisure, you probably remember that at its heart the story is about a man’s struggle for existence. If you are in recovery, you don’t have to read Kafka’s works to understand how arduous altering a single solitary thing in one’s life can be, let alone changing everything. Recovery demands a paradigm shift in thinking, or to steal a line from an even more relevant book, donning “A New Pair of Glasses.” Committing oneself to a program of long-term sobriety gives people a different perception; when the fog of alcohol and drugs lifts, you see things with clarity. When you work a program, it can completely alter your perspective, attitude, and it allows for continual growth in positive directions. A true metamorphosis, in every sense of the word!

With active drug and alcohol use behind us, we choose engagement over isolation. When Self is no longer harboring illusions of total control, one can develop a relationship with something higher. And, that something – while different for each of us – guides us both inside and out toward making the next right decision. In recovery, people have the tools to face their problems with a positive attitude; rather than recoiling from life’s curveballs, we take action. Positive Attitude Changes Everything!

Starting Over In Recovery

Nobody can deny that changing the people, places, and things in life is a difficult task. Even more challenging, is that individuals in recovery also have to change how they look at just about everything. Gone are the days of feeling sorry for one’s self; it is no longer OK to hold other people responsible for how life is today. Recovery teaches us that we have to take responsibility for our decisions and be accountable for the outcome of our choices. Equally vital, placing emphasis on staying accountable to others.

For many people new to working a program, there comes the realization that they cannot take this journey alone—just one of many critical epiphanies. When the seed of recovery is germinating, individuals have the awareness that the way life was before is no longer tenable. One must be present today, always making an effort to connect with men and women in their support network. Such people have to strive to be of service to others; individual sobriety is not mutually exclusive from collective recovery.

Early on in the quest for sobriety, men and women have to come to terms with the fact that life will never be the same. People who you once considered friends and allies, start looking decidedly less so; if recovery is to grow, pruning some of the underbrush of one’s past is a must. People’s environments need to change too; in recovery, going to a bar to catch up with friends isn’t safe. Engaging in activities that are inextricably connected to past substance use often have to go as well. In some cases, that includes places of employment.

Journey to Sobriety

While we specialize in working with men at PACE Recovery Center, there is much wisdom that we can glean from women taking the journey to sobriety. Author Kristi Coulter made a critical decision recently about the line of work she was in; a choice which many men in recovery can probably relate. Before she earned recognition for writing about her life sober, Coulter held several executive positions with Amazon. Kristi held jobs that many people could only dream of, which is why it may come as a surprise that last February Coulter quit working in the tech sector. Now, she is thoroughly committed to writing about the new quest she is on—sobriety.

Coulter got sober in 2013. Since then she has documented her life on her blog, Off-Dry, Seattle Magazine reports. With five years free from alcohol under her belt, she published a collection of essays titled "Nothing Good Can Come from This" (released August 7). She tells Woolfer in an interview that the book is about “what happens when a high-achieving, deeply unhappy fortysomething woman gives up the ‘one’ thing she really thinks she can’t live without–wine–and has to remake her entire sense of self from the ground up.” She talks about working in the high-stress tech-sector, about how alcohol use and addiction is pervasive in the industry. Like many people new to sobriety, she began penning her thoughts. An essay that she wrote was picked up and led to a book deal. Coulter says she hopes her writing will inspire others to confront their relationship with substances.

I’d love for people to think, ‘What would my life be like after I got rid of the thing that I know I don’t need but [that] I can’t seem to walk away from?’”

Addiction Recovery

At PACE, we take a dynamic approach to our men's addiction and mental health treatment program. We help clients face the underlying issues of their condition(s) and teach men how to discard self-defeating behaviors and adopt attitudes of positivity. Please contact us to learn more about how we can make the dream of recovery your long-term reality.

Addiction to Opioids and Finding Recovery

addiction

At times, the American addiction opioid epidemic appears to be an unwinnable battle. Lawmakers and public health experts continue to do everything in their power – ostensibly – to impede the trend of ever-increasing overdose death rates. Police officers and other first responders have the overdose reversal drug naloxone (Narcan) on hand. Many opioid use disorders (OUDs) and their families can acquire Narcan kits without a prescription in many parts of the country. More doctors are now exercising additional significant caution when prescribing drugs like OxyContin and Percocet. And, perhaps most vital, the states hardest hit by the epidemic are expanding access to addiction treatment. However, to everyone’s dismay, the overdose death rate continues to climb with each passing year.

The U.S. Centers for Disease Control and Prevention (CDC) issued preliminary estimates for the overdose death toll in 2017, and the findings are disconcerting. In 2016, the national overdose deaths were right around 64,000 Americans, but in 2017 the number jumped 10.2 percent with overdoses killing about 72,000. The startling number is not a final count which means there is an excellent chance that the toll is even more concerning.

In spite of all the hard work of thousands of Americans, more people than ever are caught in the vicious cycle of opioid addiction. The primary driving force behind the record-setting overdose death rates is – without any doubt – synthetic opioids like fentanyl. It is worth pointing out that there are good signs that almost get lost in the noise of data, some areas are doing better. In parts of the country hardest hit by the epidemic, there are promising indicators thanks to public health campaigns and expanding access to addiction treatment, The New York Times reports. So far in 2018, it looks like the Commonwealth of Massachusetts will see a decrease in overdose fatalities.

Tackling Widespread Opioid Use

The two driving forces behind the increase over 2016 are synthetic opioid analogs, and more people are using opioids, according to the article. Brandon Marshall, an associate professor of epidemiology at the Brown University School of Public Health, would agree with the latter, he says the number of opioid users is increasing but not exponentially.

The C.D.C reports that synthetic opioid-related overdoses rose dramatically last year, whereas heroin, prescription opioid-related deaths fell. The agency says there is some evidence that fatal overdoses may have plateaued toward the end of last year, especially in the East. But, there is a reason to suspect things could get worse on the West Coast.

Chris Jones, the director of the national mental health and substance use policy laboratory, tells the NYT that drug distributors are discovering how to mix fentanyl with black tar heroin. Unlike the East Coast, the majority of heroin used in states like California is a black tarry-ish resin iteration of the drug. Black tar – experts say – doesn’t admix as well with fentanyl like the white powder heroin does found in states east of the Mississippi.

Persisting Stigma of Addiction

In 2016, a phone survey revealed that more than 2 million Americans were struggling with opioid use disorder. However, Dan Ciccarone, a professor of family and community medicine at the University of California, San Francisco, says the actual number might be closer to 4 million Americans. Why the 2-million-person discrepancy? Stigma! Many people are reluctant to share that they have a problem, even during an anonymous phone survey. Dr. Ciccarone, who researches heroin markets, adds:

Because of the forces of stigma, the population is reluctant to seek care. I wouldn’t expect a rapid downturn; I would expect a slow, smooth downturn.”

Naturally, anyone struggling with any form of addiction can do him or herself an excellent service by seeking addiction treatment immediately. While opioids are more likely to cause an overdose death than most other drugs, harmful synthetic opiates are showing up in substances other than heroin. Mixing fentanyl with cocaine, methamphetamine, and benzodiazepines is becoming more common. Unsuspecting addicts are at high risk, and the only sure way of avoiding contact with fentanyl is abstinence and working a program of recovery.

Addiction Treatment

We understand that the decision to seek treatment isn’t made lightly, and the stigma of addiction is daunting. However, those who can find the courage to seek assistance can and do recover from the impact of drug and alcohol abuse. At PACE Recovery Center, we offer clients struggling with addiction and co-occurring mental health disorders a safe and supportive environment. Our team of highly-skilled addiction professionals helps adult males overcome the challenges they have experienced due to alcohol and substance use disorders. Please contact us today to learn more about our specialized clinical treatment for men.

PACE Recovery Center is LegitScript Certified

legitscript certified rehabAt PACE Recovery Center, we are dedicated to providing men with the skills and knowledge for working a program of long-term addiction recovery. For people to break the cycle, adopt a program of maintenance, and continue to make progress after treatment, it is vital that they have proper guidance early on in the process. It is worth remembering that successful treatment outcomes depend upon helping clients understand that practically everything has to change if recovery is to prevail.

Seeking treatment, while vital, isn’t always as simple as typing “best drug rehab” into Google. With thousands of centers to choose from, how is a person to be sure that the selected center is the right fit? The quest for reliable recovery centers to advocate for your wellbeing is compounded by the fact that websites are often deceptive regarding their quality of care. A flashy website with all the right verbiage doesn’t always match what clients actually experience.

With more people than ever seeking addiction treatment services, it’s crucial that families can find adequately vetted centers. Some of our readers may remember that Google suspended addiction treatment and rehab centers from advertising on search engines and apps last fall. The moratorium is the result of various companies’ reliance on deceptive marketing practices, essentially praying on the vulnerability of addicts, alcoholics, and their families. So, with all the misinformation about what treatment centers can provide, how is a family to know they are in good hands? One new answer is LegitScript.

Trusted Names In Addiction Treatment

Typically, the most reliable treatment options are those with specific accreditations, like that given by the Commission on Accreditation of Rehabilitation Facilities (CARF). A stamp of approval from CARF means that a provider meets rigorous standards of care and treatment practices. Merely put, a CARF-approved center means a client is in excellent hands.

Our commitment to providing potential clients assurances that choosing PACE is their safest option led us to undergo LegitScript's vetting process. A LegitScript monitored center is one that Google will allow to recommence online advertising, if they so choose, after the ban implemented in September 2017. The Portland-based company was only in the business of verifying the standards of online pharmacies and supplement providers. Now, in the wake of countless unscrupulous treatment providers’ online advertising, LegitScript adds addiction treatment to its wheelhouse.

Being LegitScript-certified means you can fully participate in online advertising, e-commerce, and payment processing programs with minimal disruptions. Many of the world’s leading companies require or recognize LegitScript Certification.”

 

PACE Recovery is Legitimate, Legal, and Trustworthy

We followed LegitScript's strict guidelines for certification, and PACE Recovery Center is now pleased to announce that LegitScript certifies PACERECOVERYCENTER.COM. After LegitScript reviewed our website and treatment practices, it was determined that we meet their “standards for legality, safety, and transparency!”

Along with our CARF accreditation, families can rest assured that their loved one is in the best possible setting for bringing about lasting recovery. If you are ready to take steps for leading a life free from drugs and alcohol, PACE Recovery Center can give you the tools and teach you how to cope with life on life’s terms. Please contact us today to learn more about our multi-pronged approach to men's addiction and mental health treatment.

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